apo 388combination of alleles at rs429358 and rs7412 variants, an individual could possess one of six common APOE genotypes (e4e4, e4e3, e4e2,e3e3, e2e3 and e2e2, appendix p 6 table2016 Nov 5;388(10057):2239-2253. doi: 10.1016S0140-6736(16)31009-1. ... concentrations. IONIS-APO(a)-L Rx mht mitate Lp(a)-mediated cardiovascular risk and is being developed