gb88B ) PAR2 antagonist GB88 (1.6 Ϯ 0.5 M) was 1000-fold more potent than ENMD-1068 (1.2 Ϯ 0.4 mM) in preventing trypsin-induced intracellular calcium release ([Ca 2 ϩ ] i ) in HMDMs ( n ϭGB88 is a synthetic organic compound that inhibits the proinflammatory and pronociceptive actions of trypsin, cathepsin-S and elastase. It is a land for the proteinase-activated receptor